Day 2 :
Nanjing Medical University Cancer Hospital & Jiangsu Cancer Hospital, China
Feng Yan is the Vice-Director of Department of Clinical Laboratory in Nanjing Medical University Cancer Hospital & Jiangsu Cancer Hospital. The research works focus on the bioanalytical chemistry in laboratory medical diagnostics. She has published more than 42 papers in reputed journals.
To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC) serum and tissue. The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed. The results showed UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p<0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p<0.001). The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.